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A B 12 -binding aptamer was identified from a pool of 10 15 molecules in 1994 and bound cyanocobalamin with tight affinity ( K D ~ 9 × 10 −8 M) but with negligible affinity for adenosylcobalamin (AdoCbl), highlighting the degree of specificity that can be afforded by an RNA aptamer [137]
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However, dramatic changes in body composition within 30 days from lipotropic injections alone are uncommon
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