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Frontiers | Dysregulated bile acid metabolism drives lipid peroxidation and ferroptosis in NAFLD: therapeutic potential for traditional Chinese medicine
Fabry disease (OMIM ID 301500) Fabry disease is a progressive, X-linked inherited lysosomal storage disorder (LSD), characterized by deficient activity of lysosomal α-galactosidase A (α-Gal A), affecting glycosphingolipid metabolism [167–170]
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220 Activation of the upstream IκB kinase (IKK) complex leads to phosphorylation and degradation of IκB, allowing NF-κB to translocate into the nucleus and initiate transcription of inflammatory mediators, including IL-8, TNF-α, GM-CSF, inducible nitric oxide synthase (iNOS), and many chemokines
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